ABG-301                      Principles of heredity                                                         2(1-1)

This is the course of under graduate level about the principles involved in heredity. The aim of the course is to understand the basic concepts in the field of genetics. The learning objective of the course is to understand how the behavior of chromosomes during Meiosis can explain Mendel’s Laws of Equal Segregation and Independent Assortment. Their key features of chromosomal behavior in meiosis that causes the alleles to be segregated. Genetics is the study of how heritable traits are transmitted from parents to offspring. Humans have long observed that traits tend to be similar in families. It wasn’t until the mid-nineteenth century that larger implications of genetic inheritance began to be studied scientifically. Genetic is the fascinating subject of biological science which offers a lot of scope for the welfare of man kind. This course covers the sequence in which the discoveries in the science of genetics were made commencing with the Mendelian genetics. Lead into the fact that the study of heredity is called genetics.  Pass out chromosome sticks and the nucleus cut from construction paper.  Review meiosis and ask what the sticks and labels are representative of based on our study of meiosis.  Use the chromosome models to lead into the concepts of: chromosome pairs, genes, dominant trait, recessive trait, heterozyous, genotype and phenotype.  This course will help the students to understand about basic knowledge of Mendelian genetics.

Contents

Theory

1. Genetics: historical development and scope.
2. Genetic basis of inheritance: cell and cell division
3. Physical basis of inheritance
4. Gametogenesis, Mendelism: basic terminology
5. Mendel's laws, monohybrid and polyhybrid crosses
6. Allelic and non-allelic interactions and examples
7. Probability: concept and laws of probability, Chi-square test and its applications
8. Modified segregation ratios, Multiple allelomorphism
9. Genetics of sex: sex determining mechanisms
10. sex linkage and its variation
11. Polygenic inheritance, Pleiotropy
12. Linkage, crossing over and chromosomal mapping, Extranuclear inheritance
13. Multiple allele and its inheritance, Genetic councelling

Practical

1. Microscopic studies on animal cells undergoing mitosis and meiosis.
2. Numerical problems on topics discussed in theory.

Recommended Texts

1. Hamilton, M. (2009). Population Genetics. UK: Wiley Blackwell. Publication.
2. Khan, F. H. & Singh, A. (2002). Principles of Genetics and Animal Breeding. India: Jaypee Brothers Medical Publishers (P) Ltd.

Suggested Books

1. Susan, L. E. (2001). Theory and Problems of Genetics; Schaum's Outline Of Genetics. USA: McGraw-Hill publisher.
2. Weaver, R. F. & Hedrick, P. W. (1997). Genetics.  Iowa, USA: WM. C. Publishers.

   Week	Topics and Readings	Book Page No.
   1	Genetics: historical development and scope. Microscopic studies on animal cells undergoing mitosis and meiosis.	A Text Book of Animal Genetics (P. Kanakaraj) (Page No. 9-16). (Page No. 27-39)
   2	Genetic basis of inheritance. Microscopic studies on animal cells undergoing mitosis and meiosis.	A Text Book of  Animal Genetics (P. Kanakaraj) (Page No. 19-24). Principles of genetics by Tamarin (Page No. 46-69)
   3	Cell and cell division Microscopic studies on animal cells undergoing mitosis and meiosis.	A Text Book of Animal Genetics (P. Kanakaraj) Page No. 27-39
   4	cell and cell division, gametogenesis; Numerical problems on topics discussed in theory.	A Text Book of  Animal Genetics (P. Kanakaraj) (Page No. 43-79),Principles of genetics by Tamarin (17-21)
   5	Mendelism: basic terminology, Numerical problems on topics discussed in theory.	Principles of genetics by Tamarin (17-21). A Text Book of  Animal Genetics (P. Kanakaraj) (Page No. 43-79),
   6	Mendel's laws, monohybrid and polyhybrid crosses, Numerical problems on topics discussed in theory.	A Text Book of  Animal Genetics (P. Kanakaraj) (Page No. 43-79),Principles of genetics by Tamarin (17-21)
   7	Probability: concept  laws of probability Mendel's laws, monohybrid and polyhybrid crosses.	A Text Book of  Animal Genetics (P. Kanakaraj) (Page No. 43-79),Principles of genetics by Tamarin (17-21)
   8	laws of probability Mendel's laws, monohybrid and polyhybrid crosses	A Text Book of  Animal Genetics (P. Kanakaraj) (Page No. 43-79),Principles of genetics by Tamarin (17-21)
   9	Chi-square test and its applications. Numerical problems on topics discussed in theory.	A Text Book of  Animal Genetics (P. Kanakaraj) (Page No. 43-79),Principles of genetics by Tamarin (17-34)
   10	Modified segregation ratios;Mendel's laws, monohybrid and polyhybrid crosses.	A Text Book of  Animal Genetics (P. Kanakaraj) (Page No. 43-79),Principles of genetics by Tamarin (17-21)
   11	Multiple allelomorphism; Mendel's laws, monohybrid and polyhybrid crosses.	A Text Book of  Animal Genetics (P. Kanakaraj) (Page No. 43-79),Principles of genetics by Tamarin (17-21)
   12	Genetics of sex: sex determining mechanisms Mendel's laws, monohybrid and polyhybrid crosses	A Text Book of  Animal Genetics (P. Kanakaraj) (Page No. 43-79),Principles of genetics by Tamarin (17-21)
   13	sex linkage and its variation. Numerical problems on topics discussed in theory.	A Text Book of  Animal Genetics (P. Kanakaraj) (Page No. 43-79),Principles of genetics by Tamarin (17-34)
   14	Polygenic inheritance; Mendel's laws, monohybrid and polyhybrid crosses.	A Text Book of  Animal Genetics (P. Kanakaraj) (Page No. 43-79),Principles of genetics by Tamarin (17-21)
   15	Pleiotropy; Linkage, crossing over and chromosomal mapping Mendel's laws, monohybrid and polyhybrid crosses.	A Text Book of  Animal Genetics (P. Kanakaraj) (Page No. 43-79),Principles of genetics by Tamarin (17-34)
   16	Extranuclear inheritance. Multiple allele and its inheritance, Genetic councelling.Numerical problems on topics discussed in theory.	A Text Book of  Animal Genetics (P. Kanakaraj) (Page No. 43-79),Principles of genetics by Tamarin (17-34)

3.                                                6 Mid,

                                                10 Theory

                                                20 Practical,

                                                Sessional:    4