The Pentose Phosphate Pathway

LEARNING OBJECTIVES
After studying this lesson, students should be able to:

  • Describe the pentose phosphate (Hexose monophosphate (HMP)) pathway: Reactions of oxidative and nonoxidative phases.
  • Explain the roles of HMP pathway as a source of NADPH and of ribose for nucleotide synthesis.
  • Describe the regulation of pentose phosphate pathway.
  • Explain the consequences of genetic defects of glucose-6- phosphate dehydrogenase (favism).