Glycolysis & the Oxidation of Pyruvate

After studying this lesson, students should be able to:

  • Describe the pathway of glycolysis and its control, and explain how glycolysis can operate under anaerobic conditions in RBCs and other tissues.
  • Explain the biomedical significance and energy yield of aerobic and anaerobic glycosis and its significance, and substrate-level phosphorylation
  • Describe the reaction of pyruvate dehydrogenase and its regulation.
  • Describe the Metabolic fates of pyruvate
  • Explain how inhibition of pyruvate metabolism leads to lactic acidosis.
  • Explain how genetic deficiency of pyruvate kinase and pyruvate dehydrogenase leads to pathology.