Gluconeogenesis & the Control of Blood Glucose

After studying this lesson, students should be able to:

  • Explain the importance of gluconeogenesis in glucose homeostasis.
  • Describe the reactions of gluconeogenesis using pyruvate and glycerol as precursors, how irreversible enzymes of glycolysis are bypassed. 
  • Explain the important gluconeogenic precursors: Entrance of amino acids, intermediates of TCA cycle, glycerol, and other compounds as gluconeogenic precursors.
  • Describe how the glycolysis and gluconeogenesis are regulated reciprocally.
  • Describe the biomedical significance of gluconeogenesis: Role of gluconeogenesis in plasma glucose level regulation, and the Cori cycle, and glucose-alanine cycle.