Active Methylene Compounds
Active Methylene Compounds: Enolization and acid/base catalyzed aldol condensations. Alkylation, arylation and acylation of acitve methylene compounds
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Course Material
- Investigation of Reaction Mechanism: Introduction
- Nature of Products and Thermodynamics requirements
- Kinetic requirements of reaction mechanism
- Study of Intermediates: Isolation, Detection and Trapping
- Stereochemical studies towards reaction mechanism
- Isotopic Studies: Isotopic labeling, Isotopic Effect, Isotopic Scrambling
- Addition reactions
- Classification of elimination reactions. E1 vs E2. Syn / anti eliminations
- MID TERM
- E1cB eliminations. Regioselectivity, Pyrolytic Eliminations, Factors affecting eliminations
- Electrophilic and Nucleophilic substitution reactions at aromatic systems
- Aliphatic Nucleophilic substitution reactions (SN1, SN2, SNi, SN1', SN2', SNi')
- Factors affecting Substitution Reactions. Neighbouring group participation
- Active Methylene Compounds
- Claisen reaction, Claisen–Schmidt reaction and Wittig reaction
- Darzen’s glycidic ester synthesis, Reformatsky reaction and Stobbes condensation
- Knovenagel reaction, Mannich reaction and Perkin reaction
- FINAL TERM
- Chapters 18
- Department Chemistry
- Teacher
Dr. Jamshed Akbar
