Basic Biochemistry (CHEM -292)

Introduction to course

• Introduction,
• Bio macromolecules
• Water Chemistry,
• Carbohydrates,
• Proteins,
• Enzymes,
• Lipids.
• Nucleic Acids,
• Vitamins

Course pre-requisites (if any)

• The prerequisites is the Physical Chemistry (CHEM 181), Inorganic Chemistry (CHEM 161) and Organic Chemistry (CHEM 271) in minimum grade “C” or better.

Learning outcomes

• Students will gain knowledge about fundamental concepts of biochemistry as well as be able to learn about the structures, properties and functions of amino acids, proteins, carbohydrates, lipids and nucleic acids and significance of vitamins in diet based upon their classification.

Textbooks (to be used for the course)

• Lehninger’s Principles of Biochemistry. (20 12) 6lio Ed. By David L. Nelson. Michael M. Cox W.H. Freeman; 6th Edition (November 21.1012).
• Principles of Biochemistry. (2011) 5th Ed. by Laurence A. Moran, Robert A Horton, Gray Scrimgeour and Marc Perry .
• Jilani Manual of Practical Chemistry, Vol-IV (2015) by Shaheen, M.A.
• Fundamentals of Biochemistry (2010) 4th Ed. by D. J. Voet, G.J. Voet and C. W. Pratt. .I. 'Wiley & Sons Inc.
• Textbook of Practical Biochemistry. Joshi A. Rashmi. B. Jain Publishers. 2002
• Introductory Practical Biochemistry. 2005. 2nd Ed. By- S. K. Sawhney, Randhir Singh. Alpha Science International, Ltd.
• Harpers Illustrated Biochemistry. (2012). 2~ Ed. By Robert Murray, David Bender.
• Kathleen M. Botham, Peter J. Kennelly, Victor Rodwell, P. Anthony Weil. McGraw-HilI
• Medical Biochemistry. 7th Ed. By Jeremy M. Berg. John L. Tymoczko and Lubert Stryer Publisher: Palgrave MacMillan; 7th Revised International Edition.

Description of system of Evaluation (Exam, assignments etc)

• Sessional                                               10%  (Minimum 75% Attendance, Behavior, Assignment)
• Mid Term Exam                                      30%       
• Project/Practical work:                            15%
• Final exam:                                             45%

Detailed lesson plans for each lecture (Weekly/Week wise)

Week 1

Definition history and Scope of Biochemistry, The molecular logic of life

Week 2

Composition and principles of organization, Origin and of biomolecules, Water: Non-covalent interactions

Week 3

Properties of water, properties. pH. Buffer and buffering capacity

Week 4

Definition and Classification, Monosaccharides, Pyranose and Furanose ring structures, Stereoisomerism and Optical isomerism

Week 5

Disaccharides: Structures. Polysaccharides. Starch, Glycogen and Cellulose. Modified Carbohydrates. Glycoproteins and Glycolipids)

Week 6

Amino acids. classification and properties. Stereochemistry. Primary. Secondary,

Week 7

Tertiary and Quaternary structures Biological functions of proteins and peptides, Protein Folding and Stability

Week 8

Chemical Nature, Nomenclature and Classification .Enzyme activity

Week 9

Mid Term Examination

Week 10

Coenzymes and immobilized enzymes, Specificity of Enzymes, Enzyme Inhibition. Regulation of Enzyme activity

Week 11

Structures and classification of Fatty Acids, essential and non-essential fatty acids, Phospholipids. Fats and oils

Week 12

Hydrogenation. Oxidation and Rancidity. Beta-oxidation of fatty acids. Lipid Bilayer, Lipid Mobility).

Week 13

(Purines and pyrimidines, nucleosides and nucleotides, Structural and functional differences between DNA and RNA.

Week 14

Types of DNA and RNA, their functions in biological systems.

Week 15

Central Dogma and its significance Fundamentals of DNA Replication, Transcription and Translation)

Week 16

Introduction. Classification, chemistry and biological 'significances of vitamins A, B & C

Week 17

Introduction. Classification, chemistry and biological 'significances of vitamins D, E and K

Week 18

 Final Term Examination

Key dates and time of class meetings

• Semester Start : 13th January 2020
  • BS Botany 4th Self-Support (2018 - 2022)

• Monday     1:00 -  2:00pm
• Tuesday     1:00 - 2:00pm
• Thursday   1:00 - 2:00pm
• Thursday.   2:00 - 4:00pm.