COURSE OUTLINE                                                                                        WINTER 2021

Course Title: Pharmaceutics-IV (Industrial Pharmacy)

Course Code: PHARM 407

DESCRIPTION & OBJECTIVES

This course is designed to broaden the student's outlook to know about all Processes and procedures adopted for the large scale Preparations of Pharmaceuticals in Industry and deepen their interest in everything that concerns general and specialized methods of preparation of Medicines in Pharmaceutical Industry. In this course, the students will also be exposed briefly to certain specific areas of tablets, capsules, aerosols, suppositories, ointments, Syrups. The lab of this course aims to provide student’s hands-on experience to Various Industrial equipment’s to enhance their skills.

This course is an instrument of satisfying the student's handling and ability to prepare various formulations.  After studying this course, students will be able to understand the pharmaceutical drug products, excipients and methods used to formulate in Pharmaceutical Industry.

INTENDED LEARNING OUTCOMES

1. To develop interest of students towards industrial processes used for the production of Pharmaceuticals
2. To provide an update on upcoming industrial improvements
3. To inculcate various techniques used in Pharmaceutical industry
4. To provide better insight to the students for equipment’s used in industry

COURSE CONTENTS

1. Mass transfer,
2. Heat transfer,
3. Theories of drying, Drying of Solids, Classification of dryers, General Methods, Fluidized Bed systems, Pneumatic systems, Spray dryer, Freeze dying,
4. Communition, Reasons for size reduction, Factors affecting size reduction, size analysis, Sieving, Energy Mills (Ball Mill, Endrumer, Edge Rumer, Disintegrant, Colloid Mill, Hammer Mill, Cutter Mill and Fluid Energy Mill etc),
5. Mixing, Fundamentals, Mechanisms, Mixing Equipment used in Liquid/Liquid, Liquid/Solid and Solid/Solid mixing,
6. Clarification and Filtration, Theory, Filter Media, Filter aids, Filter selection and Equipment (Leaf filter, Filter press, Melta filters and Rotary filters),
7. Evaporation, General principles of Evaporation, Evaporators and Evaporation under reduced pressure,
8. Compression and compaction, The solid-air Interface, Angle of Repose, Flow rates, Mass volume relationship, Density, Heckel Plots, Consolidation, Granulation, Friability, Compression (dry method, wet method, slugging), Physics of Tabletting, tabletting machines and other equipment required, problems involved in tabletting, tablet coating. Capsulation, Hard and soft gelatin capsules.

READINGS

1. The Theory and Practice of Industrial Pharmacy by Lachman

2. Tutorial Pharmacy by S.J. Carter.