Michael addition, Mannich Reaction and Robinson annulation
Course Material
- Introduction and importance of Organic Synthesis. Methods for C – C bond formation, Methods for generation of carbanions
- Enolate chemistry for C – C bond formation, Role of medium in alkylation reactions
- Kinetic vs Thermodynamic enolat, O vs C-alkylation
- Specific enolate equivalents
- Michael addition, Mannich Reaction and Robinson annulation
- Ylides in C-C bond formation. Concept of Umpolung
- Methods for C–O, C – N bond formation, Trends in organic synthesis
- Introduction and role of protective groups in organic synthesis, Protective groups for carbonyl, alcohols and amines functionalities
- Mid Term Exam
- Introduction to reterosynthesis, concept of 1,1, 1,2 disconnections, Functional group inter-conversion (FGI)
- Disconnections of alcohols and its derivatives
- Disconnections of alkenes
- Disconnections of saturated hydrocarbons
- Retrosynthesis of difunctionalized compounds
- Disconnections of 1,3-dioxygenated compounds
- Disconnections of carboxylic acids and simple carbonyl compounds
- Disconnections of 1,5-dicarbonyls
- Practice and exercise of retrosynthesis as well as synthesis of multifunctional organic compounds
- Chapters 18
- Department Chemistry
- Teacher
Dr. Humaira Yasmeen Gondal
