PREV

NEXT

• Introduction and importance of Organic Synthesis. Methods for C – C bond formation, Methods for generation of carbanions
• Enolate chemistry for C – C bond formation, Role of medium in alkylation reactions
• Kinetic vs Thermodynamic enolat, O vs C-alkylation
• Specific enolate equivalents
• Michael addition, Mannich Reaction and Robinson annulation
• Ylides in C-C bond formation. Concept of Umpolung
• Methods for C–O, C – N bond formation, Trends in organic synthesis
• Introduction and role of protective groups in organic synthesis, Protective groups for carbonyl, alcohols and amines functionalities
• Mid Term Exam
• Introduction to reterosynthesis, concept of 1,1, 1,2 disconnections, Functional group inter-conversion (FGI)
• Disconnections of alcohols and its derivatives
• Disconnections of alkenes
• Disconnections of saturated hydrocarbons
• Retrosynthesis of difunctionalized compounds
• Disconnections of 1,3-dioxygenated compounds
• Disconnections of carboxylic acids and simple carbonyl compounds
• Disconnections of 1,5-dicarbonyls
• Practice and exercise of retrosynthesis as well as synthesis of multifunctional organic compounds