Week 3: Lesson 7,8.9 Cell wall synthesis inhibitors

Some antimicrobial drugs selectively interfere with synthesis of the Bacterial cell walla structure that mammalian cells do not possess. The cell wall is composed of a polymer called peptidoglycan that consists of glycan units joined to each other by peptide cross-links. To be maximally effective, inhibitors of cell wall synthesis require actively proliferating microorganisms; they have little or no effect on bacteria that are not growing and dividing. The most important members of this group of drugs are the Beta-lactam antibiotics (named after the β-lactam ring that is essential to their activity) and vancomycin. Figure 31.1 shows the classification of agents affecting cell wall synthesis

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