COURSE OUTLINE                                                                                                             FALL 2020

Course Title:    Advance Stereochemistry

Course Code: CHEM-7139

Credit Hours:  3

Instructor:       Dr Abdul Rauf Raza, Associate Professor

Email:              [email protected]

DESCRIPTION & OBJECTIVES

Stereochemistry is the study of the relative arrangement of atoms or groups in a molecule in 3D space. Stereochemistry of molecules dictates isomerism, chemical and biochemical reactivity. These days chiral drugs have become an integral part of pharmaceutical industry and replacing racemic (enantio impure) drugs. A basic concept on 3D structures, conformations of molecules, asymmetric synthesis, other stereochemical principles and attributes are essential.

This course is aimed at our BS/MSc course CHEM-372 / 561 (Organic Chemistry-I) course as foundation knowledge. This course (CHEM-740, Advance Stereochemistry) shall lay foundation for asymmetric transformations with an emphasis on mechanisms, structure-reactivity relationships and applications in organic synthesis.

READINGS

1. Eliel, E. L. Wilen S. H. and Mander, L. N. Stereochemistry of Organic Compounds. John Wiley & Sons, New York (1994).
2. Morris, D. G. Stereochemistry. RSC (Cambridge), UK (2001).
3. North, M. Principles and Applications of Stereochemistry. Stanley Thornes Publishers Ltd (Cheltenham), UK (1998).
4. Nasipuri, D. Stereochemistry of Organic Compounds: Principles and Applications. New Age International Ltd, New Delhi (2012).
5. Gal, J., Stereochemical Vocabulary for Structures …. Chirality, 23 (2011), 647-659 (A review article).

CONTENTS

Stereochemistry of cyclic and fused systems; stereochemical outcome of addition, substitution, elimination, pericyclic reactions and molecular rearrangements; Felkin-Anh’s Principle; ee and de; stereoselectivity vs stereospecificity; asymmetric syntheses involving the use of chiral pool, chiral reagents and chiral catalysts, resolution methods.

COURSE SCHEDULE

Note: You can reserve one week for sessional or mid-term exam, and, if you wish, one week for student presentations of the assigned research project

RESEARCH PROJECT

Presentation on different current topics in due course after mid term examination on Fridays as per time table.

ASSESSMENT CRITERIA

Mid Term Examination:          30% (100% objective type)

Sessional:                                20% (Attendance = 10%, Assignments = 5%, Presentation / conduct = 5%)

Presentation:                           5% (included in sessional marks)

Participation:                           5% (included in sessional marks)   

Final examination:                   50% (60% subjective type; 40% objective; premid :postmid course = 3:7)

RULES AND REGULATIONS

Minimum attendance required for sitting in Mid/Final Exam. = 75%