Course Title: Organometallic Chemistry Course Code: CHEM-7149
Credit Hours: 3 Semester: Spring 2021
Instructor: Dr Abdul Rauf Raza, Associate Professor
Email: [email protected]
DESCRIPTION & OBJECTIVES
The Inorganic Chemistry-I (CHEM-362/551) of BS/MSc curricula is the foundation course for having a keen understanding of this course. This course shall highlight the important transformations of organoboranes, ylides (organophosphorous & organosulphur only) in addition to organotransition-metal (Li+, Mg2+, Cu+, Zn0, Zr0, Sn4+, Pd0, Pd2+, Ru3+ etc.) species with an emphasis on their synthesis, basic mechanism of action/catalysis, structure-reactivity relationships and applications in organic synthesis.
READINGS
- Astruc, D. 2007. Organometallic Chemistry and Catalysis. Springer-Verlag, Berlin (Heidelberg).
- Crabtree, R. H. 2005. The Organometallic Chemistry of Transition Metals. John Wiley & Sons, New York.
- Spessard, G.O and Miessler, G.L.1997. Organometallic Chemistry. Prentice Hall PTR.
- Spessard, Gary O., and Gary L. Miessler. Organometallic Chemistry. Upper Saddle River, NJ: Prentice-Hall, 1996.
CONTENTS
Synthesis and applications of organoLi, organoMg, organoCu, organoZn, organoSn, organoPd and organoZr compounds with stereochemical outcomes; ylides that include organoS, organoP compounds; metathesis (both first and second generation Grub’s catalysts).
COURSE SCHEDULE
|
Week |
Topics and Readings |
Dates |
|
1 |
Introduction to Organometallics, geneology of organometallics |
March 18, 2021 |
|
Coordination metal complexes (Crystal Field Theory) |
March 19, 2021 |
|
|
2 |
Applications of Crystal Field Theory |
March 25, 2021 |
|
Oxidative addition, reductive elimination, insertion reactions and trans-metallation |
March 26, 2021 |
|
|
3 |
Synthesis of highly reactive organometallics-I (OrganoLi & OrganoNa) |
April 1, 2021 |
|
Applications of organoLi |
April 2, 2021 |
|
|
4 |
Synthesis and applications of highly reactive organometallics-II (OrganoMg ≡ Grignard’s reagent) |
April 8-9, 2021 |
|
5 |
Synthesis of organoB, synthetic applications of organoB |
April 15, 2021 |
|
OrganoSi: synthesis & synthetic applications |
April 16, 2021 |
|
|
6 |
OrganoCu (Gillman’s reagent): synthesis & synthetic applications |
April 22, 2021 |
|
Synthesis of Zn* and organoZn (Reformatsky’s reagent), synthetic applications organoZn |
April 23, 2021 |
|
|
7 |
Synthesis of OrganoZr (Schwartz’s reagent) |
April 29-30, 2021 |
|
8 |
Synthetic applications of OrganoZr (Schwartz’s reagent) |
May 6-7, 2021 |
|
9 |
Eid ul Fitr |
May 13-14, 2021 |
|
10 |
Mid-Term Examination (May 17-21, 2021) |
|
|
11 |
OrganoPd (preparations), OrganoPd(II) |
May 27-28, 2021 |
|
12 |
Heck and Walker reaction, Stille coupling |
June 3, 2021 |
|
Suzuki coupling, Heck reaction followed by carbonylation |
June 4, 2021 |
|
|
13 |
Applications of organoPd |
June 10, 2021 |
|
Pd-mediated cascade cyclizations |
June 11, 2021 |
|
|
14 |
OrganoRu (Grub’s metathesis) |
June 17, 2021 |
|
Second generation Grub’s catalyst and it’s applications |
June 18, 2021 |
|
|
15 |
Applications of organoRu in cascade cyclization |
June 24, 2021 |
|
OrganoP ylides (Wittig Z-olefination, its stereocontrol) |
June 25, 2021 |
|
|
16 |
OrganoS ylides (Julia E-olefination and its stereocontrol) |
July 1-2, 2021 |
|
17 |
Other miscellaneous organometallics (like organoTi, organoRh, organoSn etc.) |
July 8-9, 2021 |
|
18 |
Final-Term Examination (July 12-16, 2021) |
|
RESEARCH PROJECT
Presentation on different current topics in due course after mid term examination.
ASSESSMENT CRITERIA
Mid Term Examination: 30%
Sessional: 20%
Presentation: included in sessional marks
Participation: Nil
Final examination: 50%
RULES AND REGULATIONS
Minimum attendance required for sitting in Mid/Final Exam. = 75%
Course Material
- Total Lessons 7
- Department Chemistry(SCB)
- About Visit Profile
-
Teacher
Dr. Abdul Rauf Raza
