Course Title:    Chemistry of Natural Products                                   Class: BS (VIII) Ex-PPP

Course Code: CHEM-479                                                                 Semester : Spring 2021                                   Credit Hours:  3+1

Instructor:       Dr Abdul Rauf Raza, Associate Professor

Email:              [email protected]

DESCRIPTION & OBJECTIVES

This course (Chemistry of Natural Products) focuses on the biosynthesis, isolation of new natural products, rational structural modifications of known natural products scaffolds for new lead discovery, total synthesis of complex natural products and green chemistry. Special emphasis is given to the development of synthetic methodologies to facilitate generation of diversity around the scaffolds, which can be utilized as key intermediates for total synthesis. The new molecular entities generated are screened for pharmacological activities with focus on cancer and anti-bacterial properties. This course is a foundation course for Natural Product Chemistry (CHEM-752) and Steroids (CHEM-914) courses of MPhil and PhD classes respectively with Organic Chemistry specialization.

READINGS

1.         Cooper, R., Nicola, G., “Natural Product Chemistry: Sources, Separations and Structure” CRC Press, Taylor & Francis (2014).        →        E-copy available

2.         Xu, R., Ye, Y., Zhao, W., “Introduction to Natural Products Chemistry” Ist Edition, CRC Press (2011).

3.            Paul M. Dewick, “Medicinal Natural Products - A Biosynthetic Approach”, 3rd Edition, Wiley England (2008).

4.         Sujata V. Bhat “Chemistry of Natural Products”, First Edition, Springer, Berlin (2005), (ISBN: 3-540-40669-7).

5.         Clayden, J; Greeves, N; Warren, S., “Organic Chemistry”
 2nd Edition, Oxford University Press, England (2008). Chapter 42 & 43         →        E-copy available

6.         Streitwieser, A., C. Heathcock and E. M. Kosower, “Introduction to Organic Chemistry”, Macmillan, New York. (1992).

CONTENTS

Theory: Introduction to natural products, classification, isolation, biosynthesis and structure elucidation of steriods, terpenoids, alkaloids, carotenes, vitamins and flavonoids.

Organic Chemistry Lab. IV (Cr.01)

1. Multistep synthesis of different types of organic compounds.

     Purification of the products by chromatographic and other techniques.

1. Isolation and purification of some natural products.
2. Confirmation of the products by different techniques e.g. elemental analysis, spectroscopy etc.                                                                                                                         

COURSE SCHEDULE

RESEARCH PROJECT

1. Multistep synthesis of different targeted organic compounds. Purification of the products by chromatographic or other techniques.
2. Isolation and purification of some natural products.
3. Confirmation of the products by different spectroscopic / spectrometric techniques e.g. IR, UV, NMR etc.

ASSESSMENT CRITERIA

Mid Term Examination (Online):          15%

Sessional:                                           15%

Practical work:                                     25%                

Presentation:                           included in sessional marks

Participation:                           included in sessional marks 

Final examination (Online):                    45%

RULES AND REGULATIONS

Minimum attendance required for sitting in Mid/Final Exam. = 75%