DESCRIPTION& OBJECTIVES

Medicinal chemistry is a fundamental course for the training of M.Phil students to learn about the principles, commercial synthesis of drugs and their therapeutic potentials. Students will learn about structure activity relations of biologically active organic molecules, i.e., drugs. Most important section is to train the students about advancement in medicines regarding drug target interactions.

READINGS

Recommended Books

1. Eliel, E.L. Wilen S.H and Mander, L.N. 1994. Stereochemistry of Organic Compounds. John Wiley & Sons, New York.
2. Morris, D.G. 2001. Stereochemistry. RSC (Cambridge), UK.
3. North, M. 1998. Principles and Applications of Stereochemistry. Stanley Thornes Publishers Ltd (Cheltenham), UK.
4. Nasipuri, D. 2012. Stereochemistry of Organic Compounds: Principles and Applications. New Age International Ltd, New Delhi.

CONTENTS

1. Introduction to medicinal chemistry,
2. structure activity relationship (SAR);
3. classification of synthetic drugs;
4. general properties, chemistry, biological action,
5. SAR and therapeutic application of alkaloids (atropine, morphine, ephedrine etc.),
6. anti-neoplastics (tamoxifen, mercaptopurine, vincristine etc),
7. antibiotics (penicillins, cephalosporins, streptomycin, tetracyclins, chloramphenicol, erythromycin’ etc.) and
8. NSAIDs.

COURSE SCHEDULE