Objective/learning outcomes

This course is designed to trained chemistry students in mass spectrometry and its applications in the structure characterization of organic molecules. The course is designed to trained the students from basic to advance level in this particular technique. In this course, mass spectrometer, ionization and ionic source, mass analyzers, metastable ion, ion detection and recording will be studied. Students will be given task to structure characterization from spectra generated by mass spectrometric techniques. The advanced modes of mass spectrometry will be studied in detail, e.g., electron impact (EI) and chemical ionization (CI), field ionization (FI), field desorption (FD), fast atom bombardment (FAB +ve and FAB –ve), plasma desorption, thermospray and electrospray mass spectra. Students will be practically trained in fragmentation pattern of common functional group. Structural elucidation using mass spectrometry in conjunction with other spectroscopic techniques will also be taken into accounts.

Contents

The mass spectrometer, ionization and ionic source, mass analyzers, metastsble ion, ion detection and recording. Electron impact (EI) and chemical ionization (CI), field ionization (FI), field desorption (FD), fast atom bombardment (FAB +ve and FAB –ve), plasma desorption, thermospray, electrospray mass spectra, fragmentation pattern of common functional group. Structural elucidation using mass spectrometry in conjunction with other spectroscopic techniques.

Readings/Books

1. Kemp, W. 1975. Organic Spectroscopy. Macmillan, London.
2. Braun, R.D. 1987. Introduction to Instrumental Analysis. McGraw-Hill, New York.
3. Williams, D.H and Fleming, I. 1995. Spectroscopic Methods in Organic Chemistry. McGraw-Hill Higher Education, New York.
4. Dyer, J.R. 1965. Applications of Absorption Spectroscopy to Organic Compounds. Prentice Hall, London.
5. House, H.O. 1972. Modern Synthetic Reactions. Benjamin, California

RESEARCH PROJECT

Presentations will be from course related topic and allocated to groups before mid-term exams and submitted to me in 16th week.

ASSESSMENT CRITERIA

Mid term examination: 30%; Sessional:  20% (Project/presentation/participation); Final exam: 50%

RULES AND REGULATIONS

75% class attendance is obligatory.