This is advanced level course designed to eleaborate and describe the role of Inorganic Chemistry in diagonosis and drug design. The course include the following topics.
Role of Micro-nutrient Elements in Human Body, Metal Bearing Enzymes and their Functions. Adverse Effects of Excess/Deficiency of Micro-nutrients. Use of Transition Elements and their Inorganic Compounds in Diagnosis and Treatment of various diseases. Metal Based Drugs, Importance of Metals and Non-metals in Biological systems. Metal ion and Chelating agents for medicinal purposes.
READINGS
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Week |
Topics and Readings |
Dates |
1. |
Role of Micro-nutrient Elements in Human Body |
First Week |
2. |
Role of Micro-nutrient Elements in Human Body |
Second Week |
3. |
Role of Micro-nutrient Elements in Human Body |
Third week |
4. |
Metal Bearing Enzymes and their Functions. |
4th Week |
5. |
Metal Bearing Enzymes and their Functions. Presentations |
5th Week |
6. |
Metal based drugs: Basic Inorganic chemistry |
6th Week |
7. |
Metal based drugs: Metallodrugs- Action Presentations |
7th Week |
8. |
Metal based drugs: Platinum based anticancer drugs: Cisplatin, carboplatin |
8th week |
9. |
Mid Examination |
9th week |
10. |
Metal based drugs: Platinum based anticancer drugs: Cisplatin, oxaliplatin, nedaplatin and other drug candidate |
10th Week |
11. |
Ruthenium based anticancer drugs, NAMI-A, KP.1029 |
11th week |
12. |
Other metal based drug candidate Presentations |
12th week |
13. |
Use of Transition Elements and their Inorganic Compounds in Diagnosis and Treatment of various diseases |
13th Week |
14. |
Use of Transition Elements and their Inorganic Compounds in Diagnosis and Treatment of various diseases |
14th week |
15. |
Importance of Metals and Non-metals in Biological systems |
15th week |
16. |
Presentations |
16th week |
17 |
Metal ion and Chelating agents for medicinal purposes. |
17th week |
18 |
Presentations/ Final Examination |
18th Week |
ASSESSMENT CRITERIA
A: Sessional
B: Mid: 15
C: Final exam: 45
D: Practical: 25