This is advanced level course designed to eleaborate and describe the role of Inorganic Chemistry in diagonosis and drug design. The course include the following topics.

Role of Micro-nutrient Elements in Human Body, Metal Bearing Enzymes and their Functions. Adverse Effects of Excess/Deficiency of Micro-nutrients. Use of Transition Elements and their Inorganic Compounds in Diagnosis and Treatment of various diseases. Metal Based Drugs, Importance of Metals and Non-metals in Biological systems. Metal ion and Chelating agents for medicinal purposes.

READINGS

 

  1. Keppler, B.K. 1993. Metal Complexes in Cancer Chemotherapy. VCH, Weinheim, Germany.
  1. Farrell, N. 2002. Coordination Chemistry Reviews. Elsevier Publishing Company.
  1. Schwietert, C.W and McCue, J.P. 1999. Coordination Chemistry Reviews. Elsevier Publishing Company.
  1. Dabrowiak, J.C. 2009. Metals in Medicine. John Wiley & Sons Ltd. UK.
  1. Keppler, B.K. 1993. Metal Complexes in Cancer Chemotherapy. VCH, Weinheim, Germany.
  1. Farrell, N. 2002. Coordination Chemistry Reviews. Elsevier Publishing Company.
  1. Schwietert, C.W and McCue, J.P. 1999. Coordination Chemistry Reviews. Elsevier Publishing Company.

 

Week

Topics and Readings  

Dates

1.

Role of Micro-nutrient Elements in Human Body

First Week

2.

Role of Micro-nutrient Elements in Human Body

Second Week

3.

Role of Micro-nutrient Elements in Human Body

Third week

4.

Metal Bearing Enzymes and their Functions.

4th Week

5.

Metal Bearing Enzymes and their Functions.

Presentations

5th Week

6.

 Metal based drugs: Basic Inorganic chemistry

6th Week

7.

Metal based drugs: Metallodrugs- Action

Presentations

7th Week

8.

Metal based drugs: Platinum based anticancer drugs: Cisplatin, carboplatin

8th week

9.

Mid Examination

9th week

10.

 Metal based drugs: Platinum based anticancer drugs: Cisplatin, oxaliplatin, nedaplatin and other drug candidate

 10th Week

11.

Ruthenium  based anticancer drugs, NAMI-A, KP.1029

11th week

12.

Other metal based drug candidate

Presentations

12th week

13.

 Use of Transition Elements and their Inorganic Compounds in Diagnosis and Treatment of various diseases

13th Week

14.

Use of Transition Elements and their Inorganic Compounds in Diagnosis and Treatment of various diseases

14th week

15.

Importance of Metals and Non-metals in Biological systems

15th week

16.

Presentations

16th week

17

Metal ion and Chelating agents for medicinal purposes.

17th week

18

Presentations/ Final Examination

18th Week

ASSESSMENT CRITERIA

 

 A:     Sessional

  1. Presentation: 5
  2. Participation:5
  3. Attendance: 5 (80% compulsory)

B:           Mid: 15

C:           Final exam: 45

D:           Practical: 25

 

Course Material