Course Title:    Spectroscopic methods in Organic CHemistry                                         Course Code: CHEM-476

Credit Hours:  3+1                                                                    Class: BS ( Regular + SS + MSc (VIII +III)                                          Semester:  (Fall 2020)

Instructor:       Dr Rizwan Nasir Paracha, Assistant Professor              Email: rizwan.nasir@uos.edu.pk

DESCRIPTION & OBJECTIVES

This course (Spectroscopic Methods in Organic Chemistry) focuses on the physical methods of characterization of isolated natural products (animal, fungal, marine and terrestrial sources), derivatives of natural products, bio/synthetic polymers and synthetic organic molecules of pharmacological importance. The new molecular entities isolated/synthesized are studied by these methods, which require only 5-10 mg quantity of the analyte as compare to chemical methods of analyses, to elucidate their molecular structure. This course does not cover the medical aspects of spectroscopy (commonly called Radiology) in broader spectrum. In fact, this course is a foundation course for Advance NMR (CHEM-7140) and advance MS (CHEM-7147) courses of MPhil with organic chemistry specialization. The practical work involves the synthesis of a few small molecules in the laboratory by a reported protocol followed by workup, purification (involving crystallization, partitioning, solvent extraction, chromatography etc.) and comparative study of IR, UV, NMR and MS spectra of substrate and product(s).

READINGS

1. Williams, D. and I. Fleming, Spectroscopic Methods in Organic Chemistry, McGrawHill, New York. (1995). 34 2. Younas, M., Orgnic Spectroscopy, A. H. Publisher, Lahore (2006). 3. Silverstein, R. M., G. C. Bassler and T. C. Morrill, Spectrometric Identification of Organic Compounds, Wiley, New York (2005). 4. Kemp, W., Organic Spectroscopy, Macmillan, London (1990).

Organic Chemistry Lab. III (Cr.01)

1. Experimental techniques e.g. distillation, solvent extraction, chromatography etc. 2. Multi-step synthesis of some organic compounds. 3. Estimation of glucose and number of acetyl groups.

RESEARCH PROJECT

Nil

ASSESSMENT CRITERIA

Mid Term Examination:                      30 %

Sessional:                                         20 %

Assignment:                                       included in sessional marks

Participation:                                       Nil 

Final examination:                              50 %

RULES AND REGULATIONS

Minimum attendance required for sitting in Mid / Final Exam. = 75%