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Objectives The course introduces students to a study of the Basic Principles of Metabolism. This course aims at introducing to students about energy production in biological systems, and the student is expected to:
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Learning Outcomes
Students will be expected to gain an understanding of the major biochemical pathways involved in metabolism in cells and tissues. Upon completion of this course students will be able to describe the key structural and functional aspects of the biochemical generation of energy as well as the chemical reactions involved in carbohydrate metabolism, the oxidation and synthesis of lipids, amino acid metabolism, nucleic acids and physiological control of metabolism.
Pre-requisites Course
General Biocemistry
Syllabus
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Introduction to Metabolism, Carbohydrate metabolism, Glycolysis, Pentose Phosphate Pathway, Gluronic acid pathway, Gluconeogenesis, Glycogenesis and Glycogenolysis, Regulation of Carbohydrate Metabolism, Photosynthesis. Lipid metabolism, Biosynthesis of Fatty Acids, Glycerides, Phospholipids and Ketone Bodies. Degradation and Biosynthesis of Sterols and Bile Acids. Regulations of Lipid Metabolism. Protein metabolism, deamination and transamination, urea cycle, metabolic disorders, TCA Cycle, Electron transport Chain, Carbohydrates Biosynthesis in Plants & Bacteria. |
Assessment Criteria
- Sessional (15): Quizzes/Tests, Assignments, Presentations/ Attendance, Class Participation
- Practical (25): lab sessions, viva voce, participation, lab book
- Midterm (15): Subjective (short questions) and Objective Questions
- Final (45): Subjective (short and long questions) and Objective Questions
Time Table
Every Monday, Tuesday, and Wednesday: 14:00 pm - 15:00 pm
Books Recommended
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- Voet, J. G. Voet, and C. Pratt, Fundamentals of Biochemistry: Life at the Molecular Level, 3rd Edition, John Wiley and Co (2008).
- Voet D.J. and J. G. Voet, Biochemistry, John Wiley and Co (2008).
- Lehninger, A. L. Principles of Biochemistry, 4th Ed. Worth Publisher, New York (2001).
- Robert, Harper’s Biochemistry, 25th Edition. (2000).
- Stryer, L. “Biochemistry”, Freeman & Co.( 1994)
- Zubay, G. “Biochemistry”, 4th Edition Macmillan Publishing Co. (1999)
- Hames and Hooper, Instant Notes in Biochemistry 2nd Ed, BIOS Publishers, Oxford (2000)
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Lippincott's Illustrated Reviews Biochemistry, 3rd Ed
Weekly Course Breakup
WEEKLY LECTURE SCHEDULE
Forty-eight Lectures (Duration: 1 hr)
|
Week |
Lecture |
Topic |
Source (Book) |
Recommendations/Learning Activities |
|
1 |
1 |
Introduction to Metabolism |
Book # 8 |
Handouts/Notes |
|
2 |
Introduction to Bioenergetics |
Book # 8, 1 |
Handouts/Notes |
|
|
3 |
Metabolic Reactions, Glucose |
Book # 2 |
Handouts/Notes |
|
|
2 |
4 |
Glucose Transport in body cells |
Book # 8 |
Class quiz |
|
5 |
Glycolysis, Hexokinase |
Book # 2, 3 |
Class Assignment |
|
|
6 |
Phospho Isomerases, PFK |
Book # 2 |
Handouts/Notes |
|
|
3 |
7 |
Aldolases, TPI, GAPDH |
Book # 2 |
Handouts/Notes |
|
8 |
Mutase, Enolase, Pyruvate Kinase |
Book # 2 |
Class quiz |
|
|
9 |
Ethanol, LDH, Decarboxylase |
Book # 2, 3, 8 |
Class Assignment |
|
|
4 |
10 |
Metabolism of Mannose, Galactose |
Book # 3, 7, 8 |
Presentations |
|
11 |
Metabolism of Glycerol, Polysaccharide |
Book # 3, 8 |
Presentations |
|
|
12 |
Glycolysis Regulation |
Book # 2, 8 |
Class quiz |
|
|
5 |
13 |
Gluconeogenesis |
Book # 2, 3, 7 |
Presentations |
|
14 |
Regulation of Gluconeogenesis |
Book # 6, 2, 8 |
Presentations |
|
|
15 |
Biosynthesis of Polysaccharides |
Book # 7 |
Presentations |
|
|
6 |
16 |
TCA Cycle Introduction |
Book # 7, 8 |
Class quiz |
|
17 |
Citrate, Aconitate, |
Book # 2 |
Class Assignment |
|
|
18 |
α-ketoglutarate, Succinate, |
Book # 2 |
Presentations |
|
|
7 |
19 |
Fumarate, Malate, OAA |
Book # 2 |
Presentations |
|
20 |
Energy Production of TCA Cycle |
Book # 2, 5, 6 |
Visual Animation |
|
|
21 |
Regulation of TCA Cycle, |
Book # 2 |
Presentations |
|
|
8 |
22 |
Anaplerotic and Anabolic TCA Cycle |
Book # 1, 2 |
Midterm Exam |
|
23 |
Glyoxylate Acid Pathway |
Book # 2, 7, 8 |
Midterm Exam |
|
|
24 |
Lipid metabolism |
Book # 8 |
Midterm Exam |
|
|
9 |
25 |
Dietary Fat Metabolism |
Book # 1, 3 |
Visual Animation |
|
26 |
β- Oxidation, Reaction 1-3 |
Book # 2, 3, 7 |
Presentations |
|
|
27 |
β- Oxidation, Reaction 4-5 |
Book # 2, 3, 7 |
Presentations |
|
|
10 |
28 |
Energetics of β- Oxidation |
Book # 2, 3, 7 |
Class quiz |
|
29 |
Oxidation of unsaturated Fatty Acids |
Book # 2, 3, 7 |
Class Assignment |
|
|
30 |
Ketone Bodies |
Book # 2, 3, 7 |
Presentations |
|
|
11 |
31 |
Biosynthesis of Glycerides |
Book # 2, 3, 7 |
Class quiz |
|
32 |
Biosynthesis of Phospholipids |
Book # 2, 3, 7 |
Presentations |
|
|
33 |
Biosynthesis of ketones |
Book # 2, 3, 7 |
Class quiz |
|
|
12 |
34 |
Biosynthesis of Sterols and Bile Acids |
Book # 2, 3, 7 |
Class Assignment |
|
35 |
Regulation of Fatty Acid Biosynthesis |
Book # 2, 3, 7 |
Presentations |
|
|
36 |
Electron Transport Chain (ETC) |
Book # 2, 3, 8 |
Handouts/Notes |
|
|
13 |
37 |
ETC Components |
Book # 2, 3, 8 |
Visual Animation |
|
38 |
Respiratory Chain Complex I & II |
Book # 2, 3, 8 |
Class quiz |
|
|
39 |
Respiratory Chain Complex III |
Book # 2, 3, 8 |
Presentations |
|
|
14 |
40 |
Respiratory Chain Complex IV |
Book # 2, 3, 8 |
Presentations |
|
41 |
Oxidative Phophorylation |
Book # 3,7, 8 |
Visual Animation |
|
|
42 |
Regulation of Oxidative Phophorylation |
Book # 2, 7, 8 |
Class quiz |
|
|
15 |
43 |
Biological Energetic, ATP, NADH, FADH2 |
Book # 3, 8 |
Presentations |
|
44 |
Free Energy Calculations, ∆G and ∆Go |
Book # 3, 8 |
Presentations |
|
|
45 |
Photosynthesis |
Book # 2, 7 |
Class quiz |
|
|
16 |
46 |
Protein metabolism |
Book # 2, 7 |
Handouts/Notes |
|
47 |
Deamination and Transamination |
Book # 2, 7 |
Handouts/Notes |
|
|
48 |
Urea Cycle, Metabolic Disorders |
Book # 4 |
Visual Animation |
- Total Lessons 0
- Department Chemistry
- About Visit Profile
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Teacher
Dr Muhammad Fayyaz ur Rehman
