Pharmacology is branch of biology concerned with study of drug action. It deals with source, chemistry, pharmacokinetics and pharmacodynamics of drugs. Chemotherapy is use of any drug to treat infectious disease.

The objective of this course are as follows:

To build up the students understanding to treat various infectious disease such as amebic dysentery, malaria and tuberculosis.

To understand mechanisms of drugs in cancer chemotherapy.

To understand the rational of therapeutics in various disease such as hepatitis, cancer etc.    

  To understand basic principles of pharmacodynamics related to drug-receptor interactions.

To apply pharmacodynamic principles to clinical practice as they relate to efficacy, potency, and toxicity of drug

Intended Outcomes   

At the end of course, the students will be able to

1.describe the basic scientific concepts and principles that serve as the foundational underpinnings of the pharmacological sciences including pharmacokinetics; pharmacodynamics; drug metabolism; and drug-drug interactions; and explain how these fundamental pharmacological properties can influence route of administration, drug action; drug efficacy and potency; drug levels in the body; potential for drug interactions; drug toxicity; and the appropriate choice of drug for pharmacotherapy in a given patient.

2. demonstrate the ability to effectively communicate and work collaboratively together with peers in the small group setting to successfully address problems of pharmacological significance

3. demonstrate professionalism by behaving in a professional and courteous manner when engaged in course activities or interacting with course faculty and staff, and by being punctual in attendance at required course activities such as small groups, team-based learning exercises and exams.

Course Contents

1. CHEMOTHERAPY:

 a) Basic principles of chemotherapy.

 b)Antibacterial: (Folate antagonists; sulphonamides. Cell wall synthesis inhibitors; Penicillin, Cephalosporins, Carbapenem, Monobactam. Protein synthesis inhibitors; Aminoglycosides, Tetracyclines, Chloramphenicol, Macrolides. Nucleic acid synthesis inhibitors; Quinolones and miscellaneous Antibiotics), Antimycobacterial drugs, Urinary tract antiseptics.

c) Anti-fungals:

d) Anti-virals: 

e) Anti-protozoals: (anti-malarias, anti-amebiasis, anthelmintics and anti- leishmanials).

f) Anti-neoplastic drugs: 

2. IMMUNOPHARMACOLOGY: Pharmacology of immuno-suppressants and stimulants.

3. TOXICOLOGY:

(a) Pollution and its types (water, air, food)

(b) Poison and principle of treatment of poisoning.

(c) Poisoning (Sign & symptom and treatment): Ethanol, Barbiturates, Digitalis, Salicylates, Strychnine, Narcotics, Nicotine, Paracetamol, Benzodiazepines and organophosphorous compounds.

(d) Chelating agents and their role in poisoning: Dimercaprol, Calcium disodium edentate (Calcium EDTA), Pencillamine and Defroxamine

Reference books

1. Harvey and Champ. Lippincott’s Illustrated Reviews. Pharmacology, 2009, 4th edition, Lippincott Williams and Wilkins, Baltimore.
2. Katzung and Trevor, basic and clinical pharmacology, 14th edition.
3. Goodman and Gilman’s the pharmacological basis of Therapeutics, Ed. Brunton, Lazo and parker 2008, 12th edition McGraw Hill, New York
4. Tripathi, KD Essentials of Medical Pharmacology by KD Tripathi, 2009. 6th edition Jayee Brothers, New Delhi.
5. Trevor, Katzung and Masters. Katzung and Trevor’s Pharmacology Examination and Board Reviews, 2008, 8th edition, McGraw Hill Lange, Boston.
6. Rang, Dale Ritter and Flower. Rang and Dale’s Pharmacology, 6th edition 2009.

Assessment method

Mid Exam: 30

Sessional:  20

Final exam: 50