Week 6: Calcium channels Blockers (CCBs)

ØVoltage-sensitive Ca2+ channels (L-type or slow channels) mediate the entry of extracellular Ca2+ into smooth muscle and cardiac myocytes and sinoatrial (SA) and atrioventricular (AV) nodal cells in response to electrical depolarization.
ØIn both smooth muscle and cardiac myocytes, Ca2+ is a trigger for contraction, albeit (awl·bee·uht) by different mechanisms. Ca2+ channel antagonists, also called Ca2+ entry blockers, inhibit Ca2+ channel function.

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