DESCRIPTION & OBJECTIVES

Pharmaceutical technology is a collective term for technologies to develop candidate compounds that have either been discovered or created into commercial pharmaceutical products. These products are made by transforming chemical compounds with useful effects on the human body into high-quality dosage forms that can appropriately exhibit effects against disease. Pharmaceutical technologies are divided into the following three functions.

• Process technology for researching synthetic methods to be used to manufacture candidate compounds efficiently and consistently in large amounts and with high quality

• Formulation technology for investigating dosage forms, formulations, and packages based on absorption stability, and usability in consideration of the characteristics of candidate compounds, and then selecting and preparing the optimal administration form

• Analytical and quality evaluation technology for establishing a variety of analytical and quality evaluation systems to properly and appropriately assure the quality of the pharmaceutical products.

Contents

1. PRINCIPLES OF PHARMACEUTICAL FORMULATION AND DOSAGE FORM DESIGN: Need for dosage form; Preformulation Studies; Product Formulation.

2. ADVANCED GRANULATION TECHNOLOGY (DESIGN & PRACTICE): Spray Drying Granulation Technology; Roller Compaction Technology; Extrusion/Spheronization as a Granulation Technique; Single Pot Processing. Granulation Technology: Rapid Release Granulation Technique; Particle Coating by Centrifugation Granulation Technology.

3. POLYMERS USED IN DRUG DELIVERY SYSTEMS:

4. NOVEL DRUG DELIVERY SYSTEM (DDS):

Sustained/ Controlled Release Drug Delivery System

i) Microencapsulation technique

 Coacervation

 Solvent evaporation

 Interfacial polymerization

 Spray drying

ii) Developmental aspects of Matrix and Reservoir Systems

READINGS

1. Augsburge, L.L. and S.W. Hoag, 2008. Pharmaceutical Dosage Forms: Tablets. Vol. 2: Rational Design and Formulation. 3rd Ed., Informa Health Care, USA. 

2. Allen, L.V., N.G. Popovich and H.C. Ansel, 2010. Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems. 9th Ed., Lippincott Williams & Wilkins, USA. 

3. Hellery, A.M., 2002. Drug Delivery and Targeting. Taylor & Francis, London, UK. 

4. Liu, D., 2008. Water Insoluble Drug Formulations. 2nd Ed. CRC Press. LLC, USA. 

5. Ahuja, S. and S. Scypinski, 2010. Handbook of Modern Pharmaceutical Analysis. 2nd Ed. Academic Press, USA. 

6. Park, K. and R.J. Mrsny, 2000. American Chemical Society Meeting Controlled Drug Delivery: Designing Technologies for the Future. American Chemical Society, USA. 

7. Banker, G.S. and T.C.T. Rhodes, 2002. Modern Pharmaceutics. 4th ed., Informa Health Care, USA.