DESCRIPTION & OBJECTIVES

Pharmaceutical technology is a collective term for technologies to develop candidate compounds that have either been discovered or created into commercial pharmaceutical products. These products are made by transforming chemical compounds with useful effects on the human body into high-quality dosage forms that can appropriately exhibit effects against disease. Pharmaceutical technologies are divided into the following three functions.

• Process technology for researching synthetic methods to be used to manufacture candidate compounds efficiently and consistently in large amounts and with high quality

• Formulation technology for investigating dosage forms, formulations, and packages based on absorption stability, and usability in consideration of the characteristics of candidate compounds, and then selecting and preparing the optimal administration form

• Analytical and quality evaluation technology for establishing a variety of analytical and quality evaluation systems to properly and appropriately assure the quality of the pharmaceutical products.

READINGS

1. Augsburge, L.L. and S.W. Hoag, 2008. Pharmaceutical Dosage Forms: Tablets. Vol. 2: Rational Design and Formulation. 3rd Ed., Informa Health Care, USA. 

2. Allen, L.V., N.G. Popovich and H.C. Ansel, 2010. Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems. 9th Ed., Lippincott Williams & Wilkins, USA. 

3. Hellery, A.M., 2002. Drug Delivery and Targeting. Taylor & Francis, London, UK. 

4. Liu, D., 2008. Water Insoluble Drug Formulations. 2nd Ed. CRC Press. LLC, USA. 

5. Ahuja, S. and S. Scypinski, 2010. Handbook of Modern Pharmaceutical Analysis. 2nd Ed. Academic Press, USA. 

6. Park, K. and R.J. Mrsny, 2000. American Chemical Society Meeting Controlled Drug Delivery: Designing Technologies for the Future. American Chemical Society, USA. 

7. Banker, G.S. and T.C.T. Rhodes, 2002. Modern Pharmaceutics. 4th ed., Informa Health Care, USA. 

CONTENTS

1. NOVEL GIT DRUG DELIVERY SYSTEM: 

a. Oral Osmotic Pumps 

b. Ion-Exchange Controlled DDS 

c. pH-Controlled DDS 

d. Bio/mucoadhesive DDS 

e. Floating DDS 

2. DRUG CARRIER SYSTEM: 

a. Liposomes 

b. Niosomes 

3. TARGETED DRUG DELIVERY SYSTEM: 

a. Active Drug Delivery System 

b. Passive Drug Delivery System 

4. PHARMACEUTICAL BIOTECHNOLOGY: 

a. Introduction to Biotechnology: Genetics/Genomics, Proteomics, Biomolecular target Identification, Pharmacogenomics, Gene therapy and Nucleic acid therapeutics. 

b. Techniques Used in Pharmaceutical biotechnology: PCR, DNA Sequencing, Affinity Protein Purification. 

c. Fundamentals of Genetic Engineering and its Application in Medicine. 

d. Pharmaceutical Recombinant therapeutic Proteins, Growth factors, Therapeutic antibodies, High-throughput screening of putative therapeutic compounds. 

e. Biotechnological aspects in the product development. 

f. Principle, Synthesis and Application of Monoclonal Antibodies. 

g. Immobilized Enzymes and their application in Medicine.