CHEM-741 (Advanced NMR Spectroscopy)

A short review of 1D NMR including chemical shift, coupling constant, spin-spin splitting etc; 13C-NMR, broad band, dept-45o, 90o and 135o; nÖe; 2D NMR; merits and demerits of each 2D NMR technique that includes homonuclear (COSY, NOESY, inadequate) heteronuclear (HMQC, HMBC, HOHAHA, TOCSY, SECSY etc); joint application of 1D and 2D NMR with IR and UV for structure elucidation, stereochemistry and dynamic studies of intermediate sized molecules

LEARNING OUTCOMES

On completion of the course, students will be able to:

• Demonstrate understanding of the basic principles of NMR
• Learn the concept of NMR of different nuclei such as 1H, 13C, 1F etc
• Basic concept and applications of 2D NMR
• Apply the concepts of ID and 2D NMR for characterization of organic  molecules.

ASSIGNMENTS

Comprehensive problem sets based on the topic covered during the lecture will be given throughout the semester. Moreover every student will be given a separate, for presentation and assignment.

RECOMMENDED READINGS

READINGSRR

1. 1. Lambert, J.B and Rittner, R. 1987. Recent Advances in Organic NMR Spectroscopy. Norell Press.
2. Croasmun, W.R and Carlson, R.M.K. 1994. 2D NMR Spectroscopy: Applications for Chemists and Biochemists. 2nd Edition. John Wiley & Sons, Canada.
3. Simpson, J.H. 2012. Organic Structure Determination using 2D NMR Spectroscopy-A Problem Based Approach. Academic Press, Oxford, UK.

ASSESSMENT

Sessional:                     20% (presentation+ assignments + class participation)

Mid Term Exam:           30%

Final exam:                   50%

              COURSE OUTLINE