This course is designed to study the advanced concepts of reactivity and selectivity in various classes of organic transformations. The course is majorly divided into two parts. Part one deals with knowledge of synthetic methodologies for bond formation i.e Carbon-Carbon and Carbon heteroatom bonds with in-depth study of chemoselectivity, regioselectivity, and stereoselectivity. The second part of this course is based on the retro-synthetic analysis. Different disconnection approaches based on logical as well as illogical strategies will be comprehended. Stepwise synthetic plans towards a broad range of organic molecules containing multifunctional groups will be designed.

LEARNING OUTCOMES

On completion of the course, students will be able to:

• Understand the basic concepts of organic reactions mechanisms, reactivity and selectivity.
• Recognize the possible outcome of any reactions under certain conditions and to choose the proper strategy for a specific target in organic synthesis
• Demonstrate an ability to design new synthetic routes from available building blocks.
• Compare synthetic strategies for a variety of multi-functional organic molecules.

  ASSIGNMENTS

Course learning goals are continuously assessed by periodic exercises relevant to lectures.  In addition each student will be given a separate topic related to organic synthesis for presentation and assignment.

RECOMMENDED READINGS

1. Paul Wyatt, Stuart Warren, Organic Synthesis: Strategy and Control, John Wiley & Sons, NY
2. Warren S., Designing organic synthesis, John Wiley & Sons, NY

3.  Paul Wyatt, Stuart Warren, Organic Synthesis, The Disconnection Approach. John Wiley & Sons,, New York

4.  F. A. Carey and R. J. Sundberg, Advanced Organic Chemistry, Part A: Structure and Mechanism. Part B: Reactions and Synthesis.

5.    Clayden J., Greeves N., and Warren S. Organic Chemistry, Oxford University Press, New York.

6.  Smith M. B., Organic Synthesis, Academic Press, USA

ASSESSMENT

Sessional:                     20% (presentation+ assignments + class participation)

Mid Term Exam:           30%

Final exam:                   50%