Introduction to Pharmaceutical Organic Chemistry includes types and properties of chemical bonds. Study the coordinating chemistry and theories that explain the connections and practical applications of composites and their role in biological systems.

Course Outline:

PHARMACEUTICAL CHEMISTRY-IA (ORGANIC) [Theory] PHARM 311 Cr. Hr. 03

NOTE: The topics will be taught with special reference to their Pharmaceutical Applications.

1. BASIC CONCEPTS: Chemical Bonding and concept of Hybridization, Conjugation, Resonance (Mesomerism), Hyperconjugation, Aromaticity, Inductive effect, Electromeric effect, Hydrogen bonding, Steric effect, Effect of structure on reactivity of compounds, Tautornerism of Carbonyl Compounds, Nomenclature of Organic Compounds.

2. STEREOCHEMISTRY/ CONFORMATIONAL ANALYSIS: Stereoisomerism, optical isomerism; Molecules with more than one chiral center, Geometrical isomerism, Resolution of racemic mixture, Conformational analysis.

3. GENERAL METHODS OF PREPARATION, PROPERTIES, IDENTIFICATION TEST AND PHARMACEUTICAL APPLICATIONS OF THE FOLLOWING CLASSES AND THEIR ANALOGUES: i. Alkane, Alkenes, Alkynes, Aromatic compounds ii. Alkyl halide, Alcohol, phenols, ethers, amines iii. Ketones, Aldehydes iv. Acids, Esters, Amides and derivative.

4. NUCLEOPHILIC, ELECTROPHILIC SUBSTITUTION REACTION IN ALIPHATIC AND AROMATIC SYSTEMS:

5. ORIENTATION IN ELECTROPHILIC SUBSTITUTION REACTIONS ON BENZENE RING:

PHARMACEUTICAL CHEMISTRY-IA (ORGANIC) [Theory] PHARM 311 Cr. Hr. 03

NOTE: The topics will be taught with special reference to their Pharmaceutical Applications.

1. BASIC CONCEPTS: Chemical Bonding and concept of Hybridization, Conjugation, Resonance (Mesomerism), Hyperconjugation, Aromaticity, Inductive effect, Electromeric effect, Hydrogen bonding, Steric effect, Effect of structure on reactivity of compounds, Tautornerism of Carbonyl Compounds, Nomenclature of Organic Compounds.

2. STEREOCHEMISTRY/ CONFORMATIONAL ANALYSIS: Stereoisomerism, optical isomerism; Molecules with more than one chiral center, Geometrical isomerism, Resolution of racemic mixture, Conformational analysis.

3. GENERAL METHODS OF PREPARATION, PROPERTIES, IDENTIFICATION TEST AND PHARMACEUTICAL APPLICATIONS OF THE FOLLOWING CLASSES AND THEIR ANALOGUES: i. Alkane, Alkenes, Alkynes, Aromatic compounds ii. Alkyl halide, Alcohol, phenols, ethers, amines iii. Ketones, Aldehydes iv. Acids, Esters, Amides and derivative.

4. NUCLEOPHILIC, ELECTROPHILIC SUBSTITUTION REACTION IN ALIPHATIC AND AROMATIC SYSTEMS:

5. ORIENTATION IN ELECTROPHILIC SUBSTITUTION REACTIONS ON BENZENE RING: