This course provides comprehensive introduction on a review of human disease with a genetic component, relating phenotype to genotype wherever possible, from monogenic disorders to complex, multifactorial diseases. More specifically, this course introduces developmental genetics, Cancer genetics, Immunogenetics, Animal models of genetic disease, Gene therapy, Genetic counseling. The overall goal of this course is to provide students with the knowledge and understanding of the scientific principles tha are the basis of current approaches to the diagnosis and management of disease. The application of these scientific principles and knowledge to the practice of medicine, including the development of life long learning and problem solving skills, is emphasized.  Learning from both basic science and clinical disciplines teach the fundamental principles of genetics. At the end of this course, students will be expected to be able to recognize patterns of inheritance, recognize the genetic and environmental contribution to multifactorial conditions and diagnosis of disease.