Principles of Genetics PBG-301

Course Title

Principles of Genetics

Course Code

PBG-301

Credit Hours

3(2-1)

Theory per week

Lecture: 2

Pre-Requisite

Nil

Category

Genetics and Molecular Biology

Aims & Objectives
  • to build understanding of the structure, function, expression and replication of genetic material
  • regulation of gene expression
  • To enable students to understand:

Chemical nature of genetic material

Genetic control of protein synthesis

Molecular basis of gene

 Mutation and its types

Learning Outcome
  • students will be able to understand the basic concepts of molecular genetics and recombinant DNA technology

Syllabus
  • Concept of genetic code and protein synthesis
  • Basic control system in Gene Expression
  • Recombinant DNA Transformation
  • Chemical nature of genetic material
  • Genetic control of protein synthesis
  • Molecular basis of gene
  •  Mutation and its types

Text Books

1. Klug, W. S. and M. R. Cummings. 2010. Concepts of Genetics. Dorling Kindersley, Pvt.(Ltd.) New Delhi, India.

2. Brooker, R. J. 2005. Genetics: Analysis and Principles. 2nd ed., McGraw-Hill Company, New York, USA.

3. Griffiths, A. J. F., J. H. Miller, D. T. Suzuki, R.C. Lewontin and W.M. Gelbart. 2005. An Introduction to Genetic Analysis. W.H. Freeman and Company, New York. USA.

4. Singh, B. D. 2004. Genetics. Kalyani Publishers, New Delhi, India.

Reference Materials

Tilman D, Kenneth G, Cassman PA, Matson RN, Stephen P (2002): Agricultural sustainability and intensive production practices. Nature 418(8):674-677.

Kumar PA (2004): Cautious use of Bt genes in transgenic crops. Current Science 86(5): 632-634.

Gepts P, Hancock J (2006): The Future of Plant Breeding. Crop Sci. 46:1630–1634.

Beurton PJ, Raphael Falk, Reheinberge HJ (2002): The concept of gene in development and evolution historical and epistemological perspective. Cambridge University Press.

 

Instructional Aids / Resources

Multimedia

Assessment Criteria

Sessional

(8)

Midterm

(12)

FinaI term

(20)

Total

(60)

Quizzer and test

3

Paper

 

Paper

 

 

Assignments

2

Project/Practical,

If require

 

Project/Practical,

If require

 

Presentations

5

Practical/Field Work

5

Attendance

2

Class Participations

3

Recommendations

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

In Case of Thirty Two Lectures (Druation: 1.5 Hours)

Frame Work

Week

Lecture

Topic

Source (Book, Chapter #, Section #)

Recommendations for Learning Activities (Mention Assignments, Test, Quizzes, Practical, Case study, Projects, Lab Work or Reading Assignments)

1
  1.  

The origin of genetics and molecular biology

Book 5; Chapter 1 Pg 3-10

Assignment1: milestones in genetics

        2.

Pleiotropy  

Book 1; Chapter 4: 41-50

 

Practical

        3

Solving problems on dihybrid and multihybrid segregating generations and backcrosses

 

Presentation topics assigned to students

2

 

        4.

gene interaction

Book 1; Chapter 4 53-57.

 
  1.  

gene interaction

Book 1; Chapter 28 570-584.

 

 
  1.  

Solving problems on dihybrid and multihybrid segregating generations and backcrosses

 

Presentations of students

 

3
  1.  

Class discussion

 

 
  1.  

quiz

 

 

 
  1.  

Solving problems on dihybrid and multihybrid segregating generations and backcrosses

 

Presentations of students

4
  1.  

Multiple alleles

Book 5; Chapter 5: 53-67

 
  1.  

Multiple alleles

Book 1; Chapter 27 549-564

 

 
  1.  

Solving problems on multiple alleles

 

Presentations of students

 

 

5

 
  1.  

Quiz and Class Discussion
  1.  

Polygenic inheritance

Book 1; Chapter 29 591-610.

 

 
  1.  

Numerical problems relating to polygenic inheritance

 

Presentations of students

6
  1.  

Sex determination

Book 1; Chapter 29 591-610.

 
  1.  

XO, XX/XY systems

Book 5; Chapter 11: 153-168

 

 
  1.  

Numerical problems relating to polygenic inheritance

 

Presentations of students

7
  1.  

sex-linkage inheritance

Book 5; Chapter 11: 153-168

 
  1.  

genic balance theory

Book 5; Chapter 11: 153-168

 

 
  1.  

Numerical problems relating to sex linkage inheritance

 

Presentations of students

8
  1.  

Holandric genes

Book 5; Chapter 11: 153-168

 
  1.  

Extra chromosomal inheritance

Book4: Chapter2: 11-104.

 

 
  1.  

Numerical problems relating to sex linkage inheritance

 

Presentations of students

9
  1.  

Linkage and Crossing Over

Book4: Chapter2: 11-104.

 
  1.  

Linkage and Crossing Over

Book4: Chapter2: 11-104.

 

 
  1.  

Numerical problems relating to linkage and crossing over

 

Presentations of students

10

 
  1.  

Class discussion

 

 
  1.  

Mid term

 

 

 
  1.  

Numerical problems relating to linkage and crossing over

 

Numerical  for practice

11

 

 
  1.  

Chromosome mapping

Book4: Chapter8: 331-391.

 
  1.  

Chromosome mapping

Book4: Chapter8: 331-391.

 

 
  1.  

Numerical problems relating to chromosome mapping

 

Numerical  for practice

 
  1.  

DNA as a genetic material

Book 2: 179-225

 

 
  1.  

Properties of genetic material

Prokaryotic and eukaryotic chromosome

Book 2: 179-225

 

 
  1.  

Numerical problems relating to chromosome mapping

 

Numerical  for practice

13
  1.  

DNA replication and protein synthesis

Book4: Chapter8: 331-391.

 
  1.  

DNA replication and protein synthesis

Book4: Chapter8: 331-391.

 

 
  1.  

Animations regarding DNA replication

13
  1.  

Genetic code

 

 
  1.  

Genetic code

 

 
  1.  

Animations regarding protein synthesis

14
  1.  

Gene mutation

 

 
  1.  

Factors affecting mutation rate

 

 
  1.  

QUIZ

15
  1.  

Transposable genetic elements

 

 
  1.  

Change in chromosome number

 

 
  1.  

Animations regarding  Transposable genetic elements

16
  1.  

Change in Chromosome structure

 

 
  1.  

Lampbrush and polytene chromosome

 

 
  1.  

FINAL TERM

Course Material

Other Courses by Saba Tabasum